An efficient and accurate distributed learning algorithm for modeling multi-site zero-inflated count outcomes

Abstract Clinical research networks (CRNs), made up of multiple healthcare systems each with patient Beta Carotene data from several care sites, are beneficial for studying rare outcomes and increasing generalizability of results.While CRNs encourage sharing aggregate data across healthcare systems, individual systems within CRNs often cannot share

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Dynamics of receptor-operated Ca2+ Currents Through TRPC Channels Controlled via the PI(4,5)P2-PLC Signaling Pathway

Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs) triggered by receptor-induced, phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).Within the vasculature, TRPC channel ROCs contribute to smooth muscle

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Evolution of acetylcholinesterase and butyrylcholinesterase in the vertebrates: an atypical butyrylcholinesterase from the Medaka Oryzias latipes.

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are thought to be the result of a gene duplication event early in vertebrate evolution.To learn more about the evolution of these enzymes, we expressed in vitro, characterized, and modeled a recombinant cholinesterase (ChE) from a teleost, the medaka Oryzias latipes.In addition to AChE, O

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